Dr. Annie Andrews is a pediatrician with nearly 20 years of clinical experience caring for South Carolina's children. A mother of three, she splits her time between Charleston, South Carolina, where her children attend public school, and Washington, D.C., where she works at a children's hospital. Andrews previously ran unsuccessfully against Republican Rep. Nancy Mace in 2022, losing in a district race centered on healthcare and abortion rights but establishing herself as a strong fundraiser. The South Carolina measles outbreak in late 2025 became a cornerstone of her campaign platform, with Andrews positioning herself as an expert voice on public health policy and misinformation prevention.
Dr. Annie Andrews is a pediatrician who has spent nearly 20 years caring for South Carolina's children in various clinical settings. She is a mother of three children who attend public school in Charleston. Andrews commutes between Charleston and Washington, D.C., where she works at a children's hospital. She holds medical credentials as a pediatrician and has built a following as a health educator on social media. Her 2022 House campaign against Nancy Mace established her as a strong fundraiser despite losing in a Republican-leaning district. She did not initially plan to pursue politics again after her 2022 loss but re-entered the race following Robert F. Kennedy Jr.'s confirmation as health secretary, citing his role in spreading vaccine misinformation that contributed to the South Carolina measles outbreak.
Strong supporter of vaccination and combating health misinformation
The South Carolina measles outbreak (120+ cases by December 2025) became the centerpiece of her campaign. Andrews has explicitly blamed RFK Jr. and his anti-vaccine disinformation for the outbreak. She made public service announcements about the disease and positioned herself as a credible medical voice against misinformation.
Voting History: As a pediatrician, not a voting record, but her professional practice demonstrates commitment to evidence-based medicine and child health
Universal healthcare advocate; focus on children and vulnerable populations
Wants to address prescription drug costs, mental health access, and healthcare for uninsured South Carolinians. Points to examples from her work: children with food insecurity, asthma worsened by mold in substandard housing, lack of mental health resources.
Graham has failed to improve South Carolina and has become more corrupt over time
Andrews argues Graham has been in office for 22 years (half of her lifetime) with little to show for it. She points to his changing positions on nearly every issue and his focus on pleasing Trump and donors rather than serving constituents.
Voting History: Not applicable as challenger; her critique centers on Graham's voting record and priorities
Andrews is not a sitting legislator, so she has no voting record. Her campaign is built on her professional expertise as a pediatrician and her previous 2022 House campaign experience.
Andrews' social media maintains a professional tone rooted in medical expertise but combines it with sharp political criticism of Graham. Her campaign video was notably aggressive and unconventional, using strong language and visual expressions of frustration. Overall, her tone balances credible expert voice with populist anti-establishment messaging.
Public service announcements about South Carolina measles outbreak; clinical explanation of the disease and importance of vaccination
Positioned Andrews as a credible expert voice during the health crisis and directly blamed misinformation for the outbreak
View post →Launch video where Andrews called Graham 'completely and unequivocally full of' expletive while banging her head on table in frustration over his position changes and Cabinet confirmations
Aggressive opening campaign message establishing Andrews as an unconventional, direct challenger willing to speak bluntly about Graham
Andrews pushes a 'radical liberal agenda that is out of touch with South Carolina' and wants to cut taxes, secure borders, protect life, defend the Second Amendment, and confirm conservative judges
Graham's campaign has framed Andrews as extreme and ideologically misaligned with South Carolina's conservative voters